During the past 20 years, tremendous advances in methods involving polymerase-chain-reaction (PCR) assays and DNA sequencing have transformed clinical virology and microbiology laboratories. These new methods allow accurate and rapid diagnosis of a wide array of infectious diseases and facilitate the monitoring of responses to the treatment of infections, such as those caused by human immunodeficiency virus and cytomegalovirus. However, there remains an important gap in our diagnostic armamentarium: rapid, reliable, easy-to-use, inexpensive diagnostic tests that can be conducted at the point of care. For years there have been calls for these types of tests in areas with limited resources, but such tests may have importance across a wide range of settings, providing results that can affect clinical decisions in real time.
Citado: Caliendo AM, Hodinka RL. A CRISPR Way to Diagnose Infectious Diseases. N Engl J Med [Internet]. 2017 [citado 7 Nov 2017];377(17).
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