Un ensayo clínico que emplea células T con su genoma editado para eliminar la molécula PD-1 ha comenzado en China con pacientes con cáncer de pulmón de células no pequeñas. El ensayo se denomina PD-1 Knockout Engineered T Cells for Metastatic Non-small Cell Lung Cancer y la noticia aparece en Cyranoski D. CRISPR gene-editing tested in a person for the first time. Nature 24 November 2016;539:479.
En la sección: Actualidades, Inmunidad tumoral, Inmunoterapia, Linfocitos T, Tecnologías. Publicado en: . 
– Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
– Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor–mediated inflammatory responses
– Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs
– Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy
En la sección: Actualidades, Ontogenia. Publicado en: .
– Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations
– Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency
– Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
– IVIG-mediated protection against necrotizing pneumonia caused by MRSA
En la sección: Actualidades. Publicado en: .
– Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
– Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator
– DNA polymerase functions in the generation of tandem mutations during somatic hypermutation of antibody genes
– CD6 modulates thymocyte selection and peripheral T cell homeostasis
– Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
En la sección: Actualidades. Publicado en: .
